Physicochemical Properties of Causative Drugs Associated with Renal Nephrotoxicity

Drugs can have both unfavorable adverse drug reactions (ADR) and useful pharmacological effects. Previous studies have reported various ADRand toxic effects caused by drugs. Those reports noted that some products were banned after being put on the market because of the severe ADR they caused, while the safety of others is assured by having usage restrictions imposed on them.

It is important not only to have a response that forms countermeasures when ADR emerge, but also to provide drug information to form safety measures to predict and avoid ADR before they occur.

There are 3 essential pieces of information about specific pharmaceutical products: physiochemical, pharmacological, and pharmacokinetic. Thus, various pharmacological and pharmacokinetic approaches that examine the association between these 3 pieces of information and adverse events caused by drugs have been previously reported. However, there are few reports that examine the association between physiochemical information and adverse events.