Drug targeting strategies through the nanostructured systems are seen to be most promising with added advantages such as improved cell permeability and retention effect of heterocyclic therapeutics for better biocompatibility. Hence, it is possible to achieve specific drug targeting with negligible side effects.
The technology and reasoning behind drug design are closely interrelated to the pre mediated inclusion of heterocyclic fragments with explicit physicochemical characteristics. Effectiveness and discernment through bio isosteric substitutions, lipophilicity, polarity, and aqueous solubility can eventually be modified to the point of changing and conditioning the possible mechanisms of action of heterocyclic drugs in an effort to attain molecularly targeted therapeutic agents. Regardless of their flexibility and effectiveness, as for any other therapeutics, there are many issues obstructing broader application and auxiliary expansion of such compounds into market drugs.
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