Since the
determination that oral calcium CaPterin is efficacious against tumor
development in murine breast cancer models and a modulator of the immuno-regulatoryenzyme indoleamine 2,3-dioxygenase (IDO), further investigation into its
mechanisms of action has been of crucial interest to investigators.
Two of
these studies also focused on the anti-tumor properties of oral dimeric DCP ,which
forms CaPterin at pH<4 (gastric conditions). This chelation dissociates
under gastric pH conditions and likely rechelates in the higher pH conditions
of the duodenum. (Read more)
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