In
recent years, the increase of mortality rates in the world is the result of a
variety of diseases associated with thrombosis or hemorrhage. Also, new data on
the role of endothelial function in ensuring system RBA has been gained as well
as its impact on thromboresistance, vascular tone and permeability, adhesion of
blood cells and angiogenesis. This allowed considering endothelial dysfunction(ED) as a key link in the pathogenesis of atherosclerosis, coronary heart
disease, hypertension cancer, diabetes, preeclampsia and many other diseases.
For the analysis of system RBA, clotting, amidolytic and immunferment methods
are used.
Detailed evaluation of conducted studies reveals a number of
disadvantages, such as lack of standardization, continuous sample preparation,
low sensitivity, and most importantly, all the methods are made on the model of
citrate plasma. Thus, constantly developing new technologies, aiming toidentify the genetic thrombophilia, markers of endothelial dysfunction,
antiphospholipid antibodies and etc., cannot solve the problem of timely
diagnosis and prevention of thrombosis and thrombohemorrhagic complications.
The global trend - the personification of research in the mode “point-ofcare
test», using “global” test evaluation system RBA, becomes popular.
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