Tuberculosis was declared as a global pandemic and panic
because the causative Mycobacterium tuberculosis can kill an incredible number
of individuals which formulate a major obstacle to social and economic
development of the country. Most of the developing countries are affected bytuberculosis. Antitubercular therapy involves the use of Directly ObservedTherapy Short (DOTS) course for 6-9 months. Antitubercular drug induced hepatic
damage may occur with DOTS combination regimen which consists of an initial
2-month phase of 1st line combination therapy with pyrazinamide (PZA),
isoniazid (INH), rifampin (RIF) and ethambutol (E) followed by a continuation
phase of treatment lasting 4 months with INH and RIF.
Metabolic idiosyncratic
reactions appear to be responsible for most drugs induced liver injury from the
first-line antitubercular medications and fluoroquinolones. Knowledge of the
mechanisms of antitubercular drug-induced liver injury or hepatotoxicity is
incomplete. Herbal drugs have gained importance and popularity in recent yearsbecause of their safety, efficacy and cost effectiveness. The association of
medical plants with other plants in their habitat also influences their
medicinal values in some cases. One of the important and well-documented uses
of ethno medicinal plant products is their use as hepatoprotective agents which
become ever increasing need for the treatment of antitubercular compounds
induced hepatic cell damage.
No comments:
Post a Comment