Comparison of Multidrug Formulations for Anti-Hypertensive Treatment

Orally Disintegrating Tablets (ODTs) are also known as orodispersible tablets, quick tablets, Fast Disintegrating Tablets (FDTs), fast dissolving tablets, rapid dissolving tablets, porous tablets, or rapidmelts. European Pharmacopoeia has recently utilized the term orodispersible tablet for tablets that disperse readily within 3 min before swallowing in the oral cavity. ODTs are disintegrated in less than one min but the time ranges from 5-30 s. ODTs help to increase the acceptability of bitter drugs by altering it to good taste and flavor to offer a pleasant mouth feeling. Some novel ODTtechnologies allow high drug loading and leaving minimal residue in the mouth. It also improves the bioavailability of a poorly soluble drug. They are characterized by high porosity, low density and low hardness. Some patented ODTs technologies include OraSolv®, Zydis®, FlashTab®, DuraSolv®, Wowtab®, etc..

ODT is prepared to enhance safety and efficacy of drug molecules by formulating a convenient dosage form for faster release; and providing ease of administration and better patient compliance. While formulating ODTs, most common challenges usually faced are palatability, mechanical strength, and hygroscopicity, the amount of drug, aqueous solubility and size