Application of PBPK Models in Personalized Healthcare

Personalized Healthcare is known as customization of healthcare, where medical decisions, and/or products are being tailored to the individual patient need with focus on special population based on different physiological and disease conditions. Personalized healthcare is a paradigm that exists more in conceptual terms thanin reality, with only a few marketed drug–test companion products and not very many actual clinical practices set up to personalize healthcare in the way that supporters have intended. In the past decades the main challenge is to manage the expectations of the medical community and the public at large that have already been set by speculation, and promises, to benefit the special populations, which includes pediatric, pregnancy, geriatric, and/or diseased conditions. 

These classes of populations were generally kept away from drug research to avoid potential harm, whereas the ratio of off-label prescription in these populations is high, ignoring lack of information. In recent yearsthere is renewed surge of interests in the applications of Physiological basedPharmacokinetic Modeling and Simulations (PBPK M&S) by pharmaceutical industry and regulatory agencies. This research is focused on the application of Physiological based Pharmacokinetic Modeling and Simulations in personalized healthcare with emphasize on pediatric populations pregnant population,population with special disease conditions including geriatric.