Among all one of the crucial factor that affects pharmacokinetic properties of drug distribution is protein binding. Of the total plasma protein by mass, protein albumin covers for approximately 60%. Hypoalbuminemia is medical condition of abnormally low blood albumin levels resulting in changes of pharmacokinetic in aspects of dosing a patient’s medication. Author has reviewed the role of coadministration of albumin in patients suffering from Hypoalbuminemia in order to optimize pharmacotherapy.
Protein binding is of great importance in pharmacokinetics and drug dosing due to the fact that protein bound drug is therapeutically unavailable for its intended action. It is only the unbound portion of the drug that is pharmacologically active. Thus, medications that are highly protein bound have a lower free fraction; the inverse relationship exists for minimally protein bound drugs.
No comments:
Post a Comment